1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-
Org 27569
CAS: 868273-06-7
Molecular Formula: C24H28ClN3O
1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]- - Names and Identifiers
1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]- - Physico-chemical Properties
| Molecular Formula | C24H28ClN3O |
| Molar Mass | 409.95 |
| Density | 1.218±0.06 g/cm3(Predicted) |
| Boling Point | 660.3±55.0 °C(Predicted) |
| Solubility | H2O: <2mg/mL |
| Appearance | powder |
| Color | white |
| pKa | 14.87±0.30(Predicted) |
| Storage Condition | 2-8°C |
| MDL | MFCD11045300 |
| Use | Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, which induces changes in CB1 receptor state by enhancing the affinity of agonists and reduces the affinity of inverse agonists. |
| In vitro study | Org 27569 is an allosteric modulator of the CB1 cannabinoid receptor. It significantly increases the binding of the CB1 receptor to the agonist and significantly reduces the specific binding of the CB1 receptor to the inverse agonist. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. Allosteric ligand Org 27569 promotes the binding of agonists to CB1, but blocks conformational changes in tm6. The Org 27569 decoy receptors bind to different agonists, but do not signal a conformational state. Org 27569 is an allosteric modulator of the CB1 cannabinoid receptor. It significantly increases the binding of the CB1 receptor to the agonist and significantly reduces the specific binding of the CB1 receptor to the inverse agonist. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. Allosteric ligand Org 27569 promotes the binding of agonists to CB1, but blocks conformational changes in tm6. The Org 27569 decoy receptors bind to different agonists, but do not signal a conformational state. |
1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]- - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| WGK Germany | 3 |
1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]- - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.439 ml | 12.197 ml | 24.393 ml |
| 5 mM | 0.488 ml | 2.439 ml | 4.879 ml |
| 10 mM | 0.244 ml | 1.22 ml | 2.439 ml |
| 5 mM | 0.049 ml | 0.244 ml | 0.488 ml |
Last Update：2024-01-02 23:10:35
1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]- - Reference Information
| Biological activity | Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, which induces changes in CB1 receptor state by enhancing the affinity of agonists and reduces the affinity of reverse agonists. Org 27569 is an allosteric modulator of cannabinoid CB1 receptor, which induces changes in CB1 receptor state by enhancing the affinity of agonists and reduces the affinity of inverse agonists. |
| In vitro study | Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptors to agonists and significantly reduces the specific binding of CB1 receptors to inverse agonists. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. The allosteric ligand Org 27569 promotes the binding of the agonist to CB1, but blocks the conformational change in TM6. Org 27569 trapping receptors bind to different agonists, but there is no signal of conformational state. Org 27569 is an allosteric modulator of CB1 cannabinoid receptor. It significantly increases the binding of CB1 receptors to agonists and significantly reduces the specific binding of CB1 receptors to inverse agonists. Org 27569 induces CB1 to bind agonists with high affinity, receptor internalization, and downstream ERK phosphorylation. The allosteric ligand Org 27569 promotes the binding of the agonist to CB1, but blocks the conformational change in TM6. Org 27569 trapping receptors bind to different agonists, but there is no signal of conformational state. |
| Features | The trap receptor binds to different agonists, but there is no signal of conformational state. |
| target | TargetValue CB1 |
| Target | Value |
Last Update：2024-04-09 21:31:59
![1H-Indole-2-carboxamide,5-chloro-3-ethyl-N-[2-[4-(1-piperidinyl)phenyl]ethyl]-](http://res.chembk.com/assets/images/structure/311334.gif)
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Product Name: Org 27569 Visit Supplier Webpage Request for quotation
CAS: 868273-06-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
CAS: 868273-06-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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